Determination of histopathological tumor grade in neuroepithelial brain tumors by using spectral pattern analysis of in vivo spectroscopic data
作者： Sebastian Herminghaus , Thomas Dierks , Ulrich Pilatus , Walter Möller-Hartmann , Jörg Wittsack
DOI: 10.3171/JNS.2003.98.1.0074
关键词:
摘要: Object. In this study, 1H magnetic resonance (MR) spectroscopy was prospectively tested as a reliable method for presurgical grading of neuroepithelial brain tumors. Methods. Using database tumor spectra obtained in patients with histologically confirmed diagnoses, 94 consecutive untreated were studied using single-voxel (point-resolved spectroscopy; TE 135 msec, TR 1500 msec). A total 90 diagnostic MR examinations analyzed commercially available software (MRUI/VARPRO) and classified linear discriminant analysis World Health Organization (WHO) Grade I/II, WHO III, or IV lesions. all cases, the classification results matched histopathological diagnoses that made according to criteria after serial stereotactic biopsy procedures open surgery. Histopathological studies revealed 30 I/II tumors, 29 III 31 tumors....
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