Preexisting CD4+ T-cell immunity in human population to avian influenza H7N9 virus: whole proteome-wide immunoinformatics analyses.

摘要: In 2013, a novel avian influenza H7N9 virus was identified in human China. The antigenically distinct surface glycoproteins raised concerns about lack of cross-protective neutralizing antibodies. Epitope-specific preexisting T-cell immunity one the protective mechanisms pandemic 2009 H1N1 even absence Hence, assessment CD4+ to conserved epitopes shared between and A viruses (IAV) is critical. comparative whole proteome-wide immunoinformatics analysis performed predict that are commonly within proteome reference IAV subtypes (H1N1, H2N2, H3N2). (∼556) were further screened against Immune Epitope Database (IEDB) validate their immunogenic potential. This revealed 45.5% (253 556) experimentally proven induce memory responses. addition, we also found 23.3% have ≥90% sequence homology with defined CD8+ epitopes. We conducted population coverage across different ethnicities using corresponding HLA-DRB1 alleles. Interestingly, indigenous populations from Canada, United States, Mexico Australia exhibited low (28.65% 45.62%) when compared other (57.77% 94.84%). summary, present demonstrate an evidence on likely presence shed light understand potential risk among populations, given high susceptibility during previous events. information crucial for public health policy, targeting priority groups immunization programs.