NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic C. elegans DEG/ENaCs
作者： Shrutika Yeola , Laura Bianchi , Shaunak Kamat , Monica Driscoll
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摘要: Hyperactivated DEG/ENaCs induce neuronal death through excessive cation influx and disruption of intracellular calcium homeostasis. C. elegans DEG/ENaC MEC-4 is hyperactivated by the (d) mutation induces touch neurons. The analogous substitution in MEC-10 (MEC-10(d)) co- expressed same neurons, only mildly neurotoxic. We exploited lower toxicity MEC-10(d) to identify RNAi knockdowns that enhance death. report here knockout nicalin homolog NRA-2 enhances MEC-10(d)-induced Cell biological assays neurons show controls
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