Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension.

摘要: Hemodynamic factors have profound influences on blood vessels. To test the hypothesis that hemodynamic conditions modify pattern of remodeling in response to injury, monocrotaline (MCT) injury Sprague-Dawley rats was followed 1 week later by left pneumonectomy increase flow right lung. Right pulmonary artery these MCT plus animals compared with receiving or alone. Neointimal changes developed more than 90% all lung intra-acinar vessels 5 weeks after (4 pneumonectomy). lesions did not develop untreated only. Animals a neointimal severe ventricular hypertrophy (RVH) whereas medial (MCT only) moderate RVH control animals. and were similar whether preceded vice versa. exclude possibility resulted from post-pneumonectomy compensatory growth, rather increased flow, subclavian-pulmonary anastomosis substituted for pneumonectomy. but seen either These studies demonstrate an important role hemodynamics determining vascular injury.