Prospective study of histomorphometry, biochemical bone markers and bone densitometric response to pamidronate in β-thalassaemia presenting with osteopenia-osteoporosis syndrome.
作者： Ratna Chatterjee , Farrukh T. Shah , Bernard A. Davis , Margaret Byers , Dev Sooranna
DOI: 10.1111/BJH.12048
关键词:
摘要: Summary This study aimed to evaluate bone remodelling disorders in thalassaemia by using pamidronate (PD) infusion with or without hormone replacement therapy (HRT) as a diagnostic-therapeutic tool. In this prospective study, 24 adult major (TM) and 10 intermedia (TI) patients received either PD HRT only (controls) for 3 years. Eugonadal TI had only. Bone was assessed dual energy X ray absorptiometry (DXA scan), type 1-collagen biochemical markers (BBM) histomorphometry of iliac crest biopsy before after PD. As group, thalassaemics significant improvement spinal femoral mineral density Z scores following (P < 0·01) compared the controls. Although BBM were comparable pre-therapy, they significantly lower cohort (P < 0·001) control group. All osteopenia, diminished osteoid formation volume on pre-therapy high turnover disease (HTO) TM low-turnover (LTO) TI. TM, improved significantly, whereas showed little no response conclusion, data suggest that have distinct pathology patients, who disease.
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