Cell to cell communication is an early event in glioblastoma

摘要: Summary Glioblastoma (GB) is the most aggressive and lethal tumour of central nervous system (CNS). GB cells proliferate rapidly display a network ultra-long microtubes (TMs) that mediate cell to communication. TMs infiltrate into brain, enwrap neurons facilitate depletion Wingless (Wg)/WNT from neighbouring neurons. establish positive feedback loop including Wg signalling upregulation activates JNK pathway matrix metalloproteases (MMPs), in turn, these signals promote infiltration, progression neuronal synapse loss degeneration. Thus, cellular molecular other than primary mutations emerge as players GB. Here we describe temporal organization events occur We define progressive activation mediated by Grindelwald (Grnd) receptor, caused ligand Eiger (Egr)/TNFα produced healthy tissue. propose interactions with rest brain an early event precedes proliferation expansion. conclude non-autonomous contribute complexity versatility incurable tumours.