Radiation-induced cognitive impairment

摘要: Radiation-induced cognitive impairment is one of the late adverse effects cranial radiation therapy (CRT) for cancer patients with primary and metastatic brain tumors, head neck cancers etc. It affects approximately 40-50% who survive >6 months severely reduces quality survivors' life. With advancement technology, survival tumor significantly improved, thus understanding etiology CRT-induced developing potential strategies management this side-effect have become more important than ever. Some valuable insights been obtained through extensive preclinical studies. suggested that radiation-induced due to dysfunctions hippocampus-dependent learning, memory spatial information processing after exposure. Until now, research results shown neurodegenerative disorders such as Alzheimer disease (AD), Parkinson's (PD), Huntington's (HD) aging-related decline, share some similar pathogenic factors, including chronic oxidative stress inflammation, in neurogenesis angiogenesis. Blockade these factors by antioxidants, anti-inflammatory drugs, transplant neural stem cells, systemic hypoxia can ameliorate decline cranially irradiated experimental animals. These studies shed light on pathogenesis may implication novel therapeutic interventions surviving suffer from CRT.