External Validation of Bloodstream Infection Mortality Risk Score in a Population-Based Cohort

摘要: A risk score was recently derived to predict mortality in adult patients with Gram-negative bloodstream infection (BSI). The aim of this study provide external validation the BSI (BSIMRS) a population-based cohort. All residents Olmsted County, Minnesota, Escherichia coli and Pseudomonas aeruginosa from 1 January 1998 31 December 2007 were identified. Logistic regression used examine association between BSIMRS mortality. Area under receiver operating characteristic curve (AUC) calculated quantify discriminative ability variety short-term long-term outcomes. Overall, 424 unique County first episodes E. P. included study. Median age 68 (range 0-99) years, 280 (66%) women, 61 (14%) had cancer 9 (2%) liver cirrhosis. associated 28-day (p <0.001) an AUC 0.86. There almost 56% increase for each point (OR 1.56, 95% CI 1.40-1.78). ≥ 5 sensitivity 74% specificity 87% negative predictive value 97%. 0.85, 0.85 0.81 7-, 14- 365-day mortality, respectively. stratified high discrimination cohort that all groups who relatively low prevalence