The occurrence of infective endocarditis with Staphylococcus lugdunensis bacteremia: A retrospective cohort study and systematic review.

摘要: Summary Background Staphylococcus lugdunensis is a coagulase-negative staphylococcus with similar virulence characteristics as aureus. Whether S. causes infective endocarditis (IE) in proportion of cases aureus (reported to be 12.6% definitive multicenter prospective study) unclear. Methods We conducted retrospective cohort study adult patients at least one blood culture positive for our institution from January 2006 December 2014. examined microbiology data, ascertained disease severity and determined the definite or possible IE based on 2000 Modified Duke Criteria. Because staphylococci were routinely identified species level 2012 onwards, we before after implementation routine speciation. also compared results reported proportions among bacteremia (SLB) other institutions by conducting systematic review scientific literature. Nonparametric bootstrapping methods performed determine 95% confidence intervals (CI) SLB. Results Seventy-four SLB identified, whom 64% (47/74) had sepsis SIRS criteria, 18% (13/74) severe illness Pittsburgh score (PBS). Kaplan–Meier survival analysis showed that one-year was worse than non-severe (p = 0.02). Fifteen percent (11/74) (95% CI 6.8–23.0%). The 15.8% (6/38, 5.3–28.9%) prior speciation 13.9% (5/36, 2.8–27.8%) (p = 0.71). Among two cultures , 25% (10/40, 12.5–40.0%) IE. Systematic literature yielded eight relevant studies. Of studies included more ranged 6.3% 27.0%. Conclusion bacteremia. fall within bootstrapping. Our findings suggest growth separate should prompt consideration workup