Hormonal control of adipocyte differentiation and adipocyte gene expression.

摘要: Publisher Summary This chapter presents a summarization of large number studies aimed at elucidating the signaling system by which determined cells decide to activate terminal differentiation program. Using adipogenic in culture, it can be documented that hormonal milieu plays major role dictating decision trigger differentiation. The effects indomethacin suggest products arachidonic acid may play key regulation cell Inhibition protein kinase C activity is important for triggering as its activation phorbol esters or certain growth factors inhibit expression differentiated phenotype. ester and factor repressible clone 5 gene an defining biochemical state associated with potential differentiation; particular, suppression appears correlate entry into nonproliferative within G1 portion cycle are incapable differentiating.