RNA Export through the NPC in Eukaryotes

摘要: In eukaryotic cells, RNAs are transcribed in the nucleus and exported to cytoplasm through nuclear pore complex. The RNA molecules that from into include messenger (mRNAs), ribosomal (rRNAs), transfer (tRNAs), small (snRNAs), micro (miRNAs), viral mRNAs. Each is transported by a specific export receptor. It believed most of mRNAs Nxf1 (Mex67 yeast), whereas rRNAs, snRNAs, certain subset Crm1/Xpo1-dependent manner. tRNAs miRNAs Xpot Xpo5. However, multiple receptors involved some RNAs, such as 60S subunit. addition these receptors, adapter proteins required RNAs. system cells also used several types virus depend on machineries host cell for replication their genome, therefore this review describes two representative viruses. We discuss NPC anchoring-dependent mRNA factors directly recruit genes NPC.