Inter-particle coating variability in a continuous coater

摘要: The influence of particle axial motion on inter-particle coating variability is studied in a rotating drum continuous coater. A mathematical framework based renewal theory developed and an expression for obtained that accounts the variance residence time particles inside This model makes no assumptions nature motion. Discrete element method simulations have shown, however, can be accurately modeled by combination advective diffusive characterized Peclet number. Using this advective-diffusive model, it was found order to maintain less than 1%, typical what might needed functional pharmaceutical tablet coatings, number 20,000 required. Such large would necessitate essentially plug flow coater lengths 1–2 m, or at least 15 m feed rates spherical diffusion coefficients.