Impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota.

摘要: The recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and decline some endangered species populations. Between December 2014 March 2015, five captive giant pandas died due canine distemper virus (CDV) infection China. CDV taken a heavy toll on tigers lions years. Here, we describe first gut microbiome diversity study CDV-infected pandas. By investigating influence bacterial communities infected uninfected individuals throughout course infection, found that distorted microbiota composition by reducing prevalence dominant genera, Escherichia Clostridium, increasing microbial diversity. Our results highlight increases intestinal inflammation changes relative abundances pathogen-containing occur when become with CDV. These may provide new insights into therapeutics target attenuate progression reduce risk gut-linked In addition, our findings underscore need for better information concerning dynamics damage caused pathogens panda