Molecular Biology of Cannabinoid Receptors

摘要: To date, two cannabinoid receptors have been isolated by molecular cloning. The CB1 and CB2 are members of the G protein-coupled receptor family. There is also evidence for additional subtypes. recognize endogenous exogenous compounds, which fall into five structurally diverse classes. Mutagenesis modeling studies identified several key amino acid residues involved in selective recognition these ligands. Numerous activation elucidated. Regions mediating desensitization internalization discovered. known genetic structures indicate polymorphisms multiple exons that may be tissue species-specific regulation genes. regulated during chronic agonist exposure, gene expression altered disease states. a complex architecture allows single to classes compounds produce an array distinct downstream effects.