Herpesvirus in the Hippocampus as a Cause of Alzheimer's Disease

摘要: To the Editor. —The fascinating account by Damasio and colleagues 1 of a patient, who suffered multimodal amnesic syndrome following bilateral temporal basal forebrain damage from herpes simplex encephalitis, echoes concept originally proposed in 1974 Penfield Mathieson, 2 suggested that hippocampal formation provides "keys access" to lifetime memory stores. In landmark article, it was surgical autopsy data not only hippocampus anatomical substrate for "lines facilitation" our neocortical storage experiential recall—what et al have phrased "the estimation spatial relationships between separate sensory information items"—but also there might even be an anteroposterior gradient these connections within itself. Mathieson wondered whether oldest memories were accessed through more posterior portion recently stored items