Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type.
作者： Gordon A. Jamieson , Norman J. Maitland , Gordon K. Wilcock , Celia M. Yates , Ruth F. Itzhaki
关键词: Alzheimer's disease 、 Temporal lobe 、 Biology 、 Pathology 、 Hippocampus 、 Herpesviridae 、 Cortex (anatomy) 、 Temporal cortex 、 Herpes simplex virus 、 Human brain
摘要: We have investigated the possible involvement of viruses, specifically Herpes simplex virus type 1, in senile dementia Alzheimer (SDAT). Using highly sensitive polymerase chain reaction, we detected viral thymidine kinase gene post-mortem brain from 14/21 cases and 9/15 elderly normals. The temporal cortex hippocampus were usually virus-positive; contrast, occipital was virus-negative 9/9 SDAT 5/5 Temporal frontal younger normals (five infants five middle-aged) negative. Thus, presence 1 DNA is a region-dependent feature aged brain.
manchester.ac.uk参考文章(8)
Alan F. Wright, Michel Goedert, Nicholas D. Hastie, Familial Alzheimer's disease. Beta amyloid resurrected. Nature. ,vol. 349, pp. 653- 654 ,(1991) , 10.1038/349653A0
D.E. Kellogg, J.J. Sninsky, S. Kwok, Quantitation of HIV-1 proviral DNA relative to cellular DNA by the polymerase chain reaction. Analytical Biochemistry. ,vol. 189, pp. 202- 208 ,(1990) , 10.1016/0003-2697(90)90108-L
C. Lynas, K. A. Laycock, S. D. Cook, T. J. Hill, W. A. Blyth, N. J. Maitland, Detection of herpes simplex virus type 1 gene expression in latently and productively infected mouse ganglia using the polymerase chain reaction. Journal of General Virology. ,vol. 70, pp. 2345- 2355 ,(1989) , 10.1099/0022-1317-70-9-2345
G K Wilcock, R A Hope, D N Brooks, P L Lantos, C Oppenheimer, G P Reynolds, M N Rossor, M B Davies, Recommended minimum data to be collected in research studies on Alzheimer's disease. The MRC (UK) Alzheimer's Disease Workshop Steering Committee. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 52, pp. 693- 700 ,(1989) , 10.1136/JNNP.52.6.693
M. J. Ball, Herpesvirus in the Hippocampus as a Cause of Alzheimer's Disease JAMA Neurology. ,vol. 43, pp. 313- 313 ,(1986) , 10.1001/ARCHNEUR.1986.00520040003001
I. Volcan, G. P. Cole, K. Johnston, A Case of Muteness of Cerebellar Origin JAMA Neurology. ,vol. 43, pp. 313- 314 ,(1986) , 10.1001/ARCHNEUR.1986.00520040003002
Gordon A. Jamieson, Norman J. Maitland, Gordon K. Wilcock, John Craske, Ruth F. Itzhaki, Latent herpes simplex virus type 1 in normal and Alzheimer"s disease brains. Journal of Medical Virology. ,vol. 33, pp. 224- 227 ,(1991) , 10.1002/JMV.1890330403
Richard J. Wurtman, Alzheimer's Disease Scientific American. ,vol. 252, pp. 62- 74 ,(1985) , 10.1038/SCIENTIFICAMERICAN0185-62