A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes

摘要: Specialization is ubiquitous in biological systems and its manifold mechanisms are active research topics. Although clearly adaptive, the way which specialization of cells realized remains incompletely understood as it requires reshaping a cell's genome to favor particular processes competition on functional capacity. Here, self-specialization mechanism identified possible role jumping genes, LINE-1 retrotransposition. The self-limiting consistent with evolutionary preservation despite likely gene-breaking effects. scenario we studied was need for cell process longer exposition an extraordinary situation, example continuous exposure nociceptive input or intake addictive drugs. Both situations may evolve toward chronification. involves within gene set subset genes cooperating processes. carries piece information, consisting sequence, about destruction their competitor not involved that process. During transcription, copy co-transcribed. At certain low probability, subsequently transcribed thus actually exposed can be rendered nonfunctional by retrotransposition relevant part. As needs time unlikely retrotranspose into own carrier gene. This reshapes self-specializing those carried out high number containing genes. Self-termination achieved allowing also occasionally jump coding region itself, destroying information successively decreasing until ceases. Employing computational genomics approach, demonstrate plausibility genomic datasets potentially chronifying interpret our results relation complex response persistent challenge met traits.