Commonalities Between Pain and Memory Mechanisms and Their Meaning for Understanding Chronic Pain

摘要: Pain sensing neurons in the periphery (called nociceptors) and central that receive their projections show remarkable plasticity following injury. This results amplification of pain signaling is now understood to be crucial for recovery survival organisms These same mechanisms may drive a transition nonadaptive chronic state if they fail resolve termination healing process. Remarkable advances have been achieved past two decades understanding molecular underlie The bear striking resemblance involved learning memory processes other brain regions, including hippocampus cerebral cortex. Here those mechanisms, commonalities subtle differences, will highlighted role causing discussed. Arising from these data argument disease nervous system, which distinguishes this phenomena acute frequently symptom alerting organism has important implications development modifying therapeutics.