Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses.

摘要: Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to undergo marked numerical changes with age in humans, our understanding of how MAIT altered during different phases across the human life span is largely unknown. also abundant tissues, study focuses on cell analyses blood. Across span, we show that naive-like umbilical cord blood switch a central/effector memory-like profile sustained into older age. Whereas low-grade levels plasma cytokine/chemokine were apparent donors (>65 y old), surprisingly, they did not correlate ex vivo hyperinflammatory cytokine observed adults. Removal from individuals and an aged environment resulted reversal baseline effector molecule comparable younger An upregulated basal inflammatory accounted reduced Escherichia coli-specific compared their young adult counterparts when fold change expression GzmB, CD107a, IFN-γ, TNF was examined. However, magnitude antimicrobial MR1-dependent activation remained as potent polyfunctional Paired TCRαβ revealed large clonal expansions adults tissues rivalled, remarkably, repertoire diversity virus-specific CD8+ cells. These data suggest individuals, although associated increased potential, demonstrate plasticity provide immunity.