Diffusion-osmotic controlled drug-release pharmaceutical composition and process for preparing same

摘要: The invention relates to a novel diffusion-osmotic controlled drug-release pharmaceutical composition containing one-layer tablet core including polymeric film-coat, therapeutically active agent and hydrophilic polymer; if desired, two-layer polymer in the first layer thereof second thereof; at least one bore on part of film-coat contact with or agent; and, more bore(s) polymer, which comprises an ammonium methacrylate copolymer as coating material hydroxypropyl-methylcellulose polymer. according is useful for preparing tablets agents e.g. β-adrenergic inhibitors (e.g. propranolol) calcium-antagonists nifedipine), angiotensin convertase enzyme (ACE) captopril); prazosin; nitroglycerol, all used heart circulation diseases; vasodilatory pentoxyfylline), nonsteroidal antiinflammatory naproxene), analgetic drugs morphine) acting central nervous system amitriptyline, buspiron). furthermore process preparation above compositions.