Fatty acid accretion in fetal and neonatal liver: Implications for fatty acid requirements

摘要: The fatty acid content of liver was determined during the last trimester infant growth and first 4 months life in order to estimate levels developing assess minimal requirements for tissue synthesis. Accretion rates were computed by regression analysis on determinations total lipid extracts from infants varying developmental ages. During growth, accretion most acids paralleled increases weight with exception C18:3, ω-3. This remained at consistently low represented <10% ω-3 present liver, even though significant longer chain homologues occurred final trimester. For term studied, increase did not occur early weeks life. However, major declined five apparently reflecting mobilization saturated, ω-9 liver. four C18:2, ω-6 increased about 3.5-and 2-fold, respectively. After initial 5 week lag net other components also These changes are quantitatively relevant estimating magnitude potential essential reserve that may be human neonate.