Microdosimetric calculations of boron-drug compound factors for boron neutron capture therapy

摘要: The relative biological effect (RBE) is not a useful term to describe {sup 10}B capture events because dose greatly for boron neutron therapy (BNCT), and each drug compound exhibits unique pharmacokinetics, resulting in differences spatial distributions tremendous variation effect. These considerations have led the suggestion that quantity called factor' (CF) be defined. CF can replace RBE BNCT terminology avoid some misinterpretations caused by quoting values. A study was performed estimate CFs normal brain brain-tumor tissues borocaptate sodium (Na{sub 2}B{sub 12}H{sub 11}SH (BSH)) para-boronophenylalanine (p-BPA). Monte Carlo computer model of capillaries used determine charged-particle energy deposition patterns following various regions within around endothelial cell. spherical tumor cells also transport tumor. were assumed 10 {mu}m diameter with 5-{mu}m-diam nuclei, extracellular space occupied 15% volume. From these results, transmission factors obtained nucleus due anymore » region external cells.« less