Common Challenges and Problems in Clinical Trials of Boron Neutron Capture Therapy of Brain Tumors

摘要: Clinical trials for binary therapies, like boron neutron capture therapy (BNCT), pose a number of unique problems and challenges in design, performance, interpretation results. In beam development, different groups use optimization parameters, resulting beams being considerably from each other. The testing, execution patient pharmacokinetics the evaluation results these studies differ widely. Finally, clinical involving treatments vary many aspects such as their dose escalation strategies, treatment planning methodologies, reporting data. implications differences data accrued are discussed. BNCT community needs to standardize aspect implementation, so that can be used meaningfully.