摘要: Human rhinoviruses (HRVs) are a major cause of the common cold. The more than one hundred serotypes, divided into species HRV-A and HRV-B, either bind intercellular adhesion molecule 1 (major group viruses) or members low-density lipoprotein receptor (minor for cell entry. Some HRVs can also access host via heparan sulphate proteoglycans. attachment protein(s) recently discovered phylogenetic clade HRV-C is unknown. respective receptors direct virus uptake clathrin-dependent independent endocytosis macropinocytosis. Triggered by ICAM-1 and/or low pH environment in endosomes virions undergo conformational alterations giving rise to hydrophobic subviral particles. These handed over from endosomal membrane. According current view, RNA genome released through an opening at fivefold axes icosahedral capsid crosses membrane pore presumably formed viral proteins. Alternatively, may be ruptured allowing particles enter cytosol. Whether channel disrupted most probably depends on HRV receptor. Copyright © 2010 John Wiley & Sons, Ltd.
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