Synaptic and Cellular Consequences of Hearing Loss

摘要: Hearing loss reduces synaptic activity in the central nervous system (CNS), and this commonly disrupts electrical properties of CNS, principally voltage-gated currents. Although no single principle explains each cellular alterations, many these changes appear to be compensatory. That is, they serve increase a neuron’s excitability, presumably response diminished sound-evoked input. This chapter explores how age hearing extent cochlear dysfunction influence properties. Thus, during development usually elicits more dramatic properties, are found throughout entire auditory neuraxis. Surprisingly, even moderate can lead alterations that as significant those produced by damage. The perceptual abilities accompany have clear peripheral bases, but studies discussed suggest CNS may equal contributors.