Role of microRNAs in vascular diseases, inflammation, and angiogenesis

摘要: The integrity of the endothelial monolayer is fundamental for homoeostasis vascular system. Functional cells are also required growth new blood vessels during neovascularization. Although multiple factors have been shown to regulate angiogenesis and development, little known about complex upstream regulation gene expression translation. MicroRNAs (miRNAs) an emerging class highly conserved, non-coding small RNAs that on post-transcriptional level by inhibiting translation protein from mRNA or promoting degradation mRNA. More than 500 human miRNAs identified so far, increasing evidence indicates distinct profiles play crucial roles in various physiological pathological processes such as cardiogenesis, haematopoietic lineage differentiation, oncogenesis. Meanwhile, a few specific cell functions described. Let7-f, miR-27b, mir-130a were pro-angiogenic miRNAs. In contrast, miR-221 miR-222 inhibit migration, proliferation, vitro targeting stem factor receptor c-kit indirectly regulating nitric oxide synthase expression. Moreover, some involved tumour miR-17-92 cluster miR-378. Early studies indicate contribution (e.g. miR-155, miR-21, miR-126) inflammation diseases. Thus, identification their respective targets may offer therapeutic strategies treat diseases atherosclerosis, improve neovascularization after ischaemia, prevent progression.