In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent.

摘要: The etiology of polyarteritis nodosa (PAN) and localized PAN is still unknown, although a T cell-mediated immune mechanism has been considered. CD8 cells participate not only in the antigen-dependent adaptive system, but also antigen-independent innate system. Non-antigen-activated express unique phenotype: granzyme B (GrB) positive /CD25 negative /programmed death-1 (PD-1) negative. aims this study were to assess participation cells, especially development vasculitis. Twenty-eight consecutive cases skin biopsy specimens with cutaneous vasculitis small muscular arteries (CVSMA) retrieved. series comprises 21 arteritis, three PAN, four rheumatoid Cases antineutrophil cytoplasmic antibody-associated excluded. phenotypes infiltrating lymphocytes lesions evaluated by immunohistochemistry. In most CVSMA, number intima was higher than that CD4 significant numbers GrB-positive which represent activated observed. However, GrB/CD25-double-positive correspond antigen-activated very few cases. Cells for PD-1, expressed on detected. We conclude mechanism, involving cytotoxic may play role CVSMA. Low expression CD25 suggests activation antigen-independent.