Voluntary ingestion of buprenorphine in mice

摘要: Buprenorphine is a widely used analgesic for laboratory rodents. Administration of the drug in desirable food item voluntary ingestion an attractive way to administer non-invasively. However, it vital that animals ingest buprenorphine-food-item mix as desired. The present study investigated how readily female and male mice (Mus musculus) two different strains consumed buprenorphine mixed commercially available nut paste (NutellaReg.), whether variation between genders would affect subsequent serum concentrations buprenorphine. at NutellaReg. was given C57BL/6 BALB/c complete cross-over study. Pure or (1.0-3.0 mg kg-1 bodyweight [bw]) 10 g bw were 1500h. video recorded until next morning, when blood collected by submandibular venipuncture. concentration did not duration any groups. significantly faster than males. Repeated exposure reduced start time ingestion, but eating mixture. These differences however measured 17 h post administration.