Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance

摘要: Failed axon regeneration and retinal ganglion cell (RGC) death after trauma or disease, including glaucomatous mitochondrial optic neuropathies, are increasingly linked to dysfunction. Mitochondria highly dynamic organelles whose size, organization, function regulated by a balance between fission fusion. ubiquitous in axonal growth cones both vitro vivo during development regeneration. However, the roles that fusion dynamics play cone largely unstudied. Here we discuss recent data suggesting mitochondria distal central role integrating intrinsic states with signaling from extrinsic cues. Mitochondrial intrinsically of acutely purified embryonic postnatal RGCs differing potentials. These differences correlate bioenergetics; high potential rely more on glycolysis whereas low oxidative phosphorylation. also differentially modulated KLFs either promote suppress growth, altering can regulate rate guidance responses inhibitory permissive