Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau.
作者： Tetsuya Kimura , Shunji Yamashita , Tetsuya Fukuda , Jun-Mi Park , Miyuki Murayama
关键词:
摘要: To investigate how tau affects neuronal function during neurofibrillary tangle (NFT) formation, we examined the behavior, neural activity, and neuropathology of mice expressing wild-type human tau. Here, demonstrate that aged (>20 months old) display impaired place learning memory, even though they do not form NFTs or loss. However, soluble hyperphosphorylated synapse loss were found in same regions. Mn-enhanced MRI showed activity parahippocampal area is strongly correlated with decline memory as assessed by Morris water maze. Taken together, accumulation mice, leading to inhibition areas, including entorhinal cortex, may underlie impairment. Thus, occurs before NFT formation cortex contribute problems seen Alzheimer's disease (AD).
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