Chapter 17 Neuronal cytoskeleton in aging and dementia

摘要: Publisher Summary This chapter discusses the morphology and biochemistry of neurofibrillary changes their analogs in animal models. One cellular molecular with aging is formation argentophilic intracellular tangles selected neurons aged human brain. These extraordinary are seen great abundance several adult late life dementias, especially Alzheimer disease/senile dementia type (AD/SDAT). The (ANT) composed paired helical filaments (PHF). Bundles these PHF also found dystrophic neurites neuritic (senile) plaque, second leading histopathological lesion AD/SDAT. normal neurofibrils microtubules, neurofilaments, microfilaments. microtubules neuron apparently identical to those glial cells all eukaryotic cells. have, by sodium dodecyl sulfate polyacrylamide gel electrophoresis, a heterogeneous polypeptide composition, which might vary from 2–3 major bands 45 kDa–62 kDa area ladder polypeptides weight difference less than 5 between adjacent bands. protein composition isolated different that plaque amyloid, scrapie-associated fibrils. Although number brain have been shown cross-react immunochemically PHF, only presence microtubule-associated proteins, tau, has demonstrated.