Role of endothelial selectins in wound repair.

摘要: P- and E-selectins are adhesion molecules expressed on activated endothelium platelets at sites of vascular injury inflammation. The selectins important for leukocyte recruitment. Because little is known about the role in wound healing, we studied cutaneous repair full-thickness excisional skin wounds mice lacking P-selectin, E-selectin, or both these selectins. absence either selectin alone had no notable effect only deficit observed was a delay early neutrophil extravasation P-selectin-deficient mice. Mice deficient markedly reduced recruitment inflammatory cells impaired closure wounds. Wound sections, up to 3 days after wounding, showed significant impairment influx. Macrophage numbers were also double mutants 7 wounding as compared with wild-type Additionally, wider epithelial gap E-selectin-double-deficient indicated delayed keratinocyte migration. These results demonstrate an combined processes leading healing.