Hydrophilic interaction chromatography of polar and ionizable compounds by UHPLC
作者： Lucie Nováková , Lucie Havlíková , Hana Vlčková
DOI: 10.1016/J.TRAC.2014.08.004
关键词:
摘要: Abstract In recent years, the popularity of hydrophilic interaction chromatography (HILIC) in analysis small polar and ionizable molecules increased substantially. A large number new stationary phases with sub-2-µm superficially porous particles were developed used various applications, including pharmaceuticals, metabolites, biomarkers, amino acids peptides. Applications HILIC ultra-high performance liquid (UHPLC) mode constitute only about 10% all current applications. This review presents an overview UHPLC mode, importance final sample diluent, a discussion on available approaches to detection, comparison other chromatographic modes.
sci-hub.se 参考文章(89)
Eric S. Grumbach, Pamela C. Iraneta, Jeffrey R. Mazzeo, Bonnie Alden, Diane M. Wagrowski-Diehl, Hydrophilic Interaction Chromatography Using Silica Columns for the Retention of Polar Analytes and Enhanced ESI-MS Sensitivity Lc Gc North America. ,vol. 22, pp. 1010- 1023 ,(2004)
Jean-Luc Veuthey, Davy Guillarme, Isabelle Kohler, Aurélie Claudine Periat, Advances in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis Lc Gc Europe. ,vol. 26, pp. 17- 23 ,(2013)
Yuanzhong Yang, Reinhard I. Boysen, Milton T.W. Hearn, Hydrophilic interaction chromatography coupled to electrospray mass spectrometry for the separation of peptides and protein digests Journal of Chromatography A. ,vol. 1216, pp. 5518- 5524 ,(2009) , 10.1016/J.CHROMA.2009.05.085
Jonathan Bones, Niaobh McLoughlin, Mark Hilliard, Kieran Wynne, Barry L Karger, Pauline M Rudd, None, 2D-LC Analysis of BRP 3 Erythropoietin N-Glycosylation using Anion Exchange Fractionation and Hydrophilic Interaction UPLC Reveals Long Poly-N-Acetyl Lactosamine Extensions Analytical Chemistry. ,vol. 83, pp. 4154- 4162 ,(2011) , 10.1021/AC200406Z
Sheng Guo, Jin-ao Duan, Dawei Qian, Hanqing Wang, Yuping Tang, Yefei Qian, Dawei Wu, Shulan Su, Erxin Shang, None, Hydrophilic interaction ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry for determination of nucleotides, nucleosides and nucleobases in Ziziphus plants. Journal of Chromatography A. ,vol. 1301, pp. 147- 155 ,(2013) , 10.1016/J.CHROMA.2013.05.074
Piliang Hao, Jingru Qian, Bamaprasad Dutta, Esther Sok Hwee Cheow, Kae Hwan Sim, Wei Meng, Sunil S. Adav, Andrew Alpert, Siu Kwan Sze, Enhanced separation and characterization of deamidated peptides with RP-ERLIC-based multidimensional chromatography coupled with tandem mass spectrometry Journal of Proteome Research. ,vol. 11, pp. 1804- 1811 ,(2012) , 10.1021/PR201048C
David V. McCalley, Is hydrophilic interaction chromatography with silica columns a viable alternative to reversed-phase liquid chromatography for the analysis of ionisable compounds? Journal of Chromatography A. ,vol. 1171, pp. 46- 55 ,(2007) , 10.1016/J.CHROMA.2007.09.047
James Heaton, Nicola Gray, David A. Cowan, Robert S. Plumb, Cristina Legido-Quigley, Norman W. Smith, Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines Journal of Chromatography A. ,vol. 1228, pp. 329- 337 ,(2012) , 10.1016/J.CHROMA.2011.09.026
James C. Heaton, Joseph J. Russell, Tim Underwood, Robert Boughtflower, David V. McCalley, Comparison of peak shape in hydrophilic interaction chromatography using acidic salt buffers and simple acid solutions. Journal of Chromatography A. ,vol. 1347, pp. 39- 48 ,(2014) , 10.1016/J.CHROMA.2014.04.026
Shinsuke Inagaki, Takumi Noda, Jun Zhe Min, Toshimasa Toyo’oka, Metabolic profiling of rat hair and screening biomarkers using ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry Journal of Chromatography A. ,vol. 1176, pp. 94- 99 ,(2007) , 10.1016/J.CHROMA.2007.10.065