Advances in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis

摘要: Hydrophilic interaction liquid chromatography (HILIC) has recently become more important, particularly for the analysis of polar drugs, metabolites and biologically relevant compounds in glycomics, proteomics, metabolomics clinical analysis. HILIC makes it possible to increase retention coumpounds, achieve orthogonal selectivity mass spectrometry (MS) sensitivity, compared with reversed-phase chromatography. This article discusses advantges limitations a variety practical applications pharmaceutical industry.