Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings

摘要: Background The relatives of individuals with schizophrenia exhibit deficits overall frontal lobe volume, consistent a genetic contribution to these deficits. Aims To quantify the structure gyral-defined subregions prefrontal cortex in and their siblings. Method Grey matter cortical thickness, surface area superior, middle inferior gyri were measured participants unaffected (non-psychotic) siblings ( n = 26 pairs), controls 40 pairs). Results volume was reduced schizophrenia, relative controls. However, only gyrus also those yielding intermediate between affected controls. Conclusions may be differentially influenced by factors being most related familial risk.