Membrane protein structural biology using X-ray free electron lasers.
作者： Richard Neutze , Gisela Brändén , Gebhard FX Schertler
DOI: 10.1016/J.SBI.2015.08.006
关键词:
摘要: Membrane protein structural biology has benefitted tremendously from access to micro-focus crystallography at synchrotron radiation sources. X-ray free electron lasers (XFELs) are linear accelerator driven sources that deliver a jump in peak brilliance of nine orders magnitude and represent disruptive technology with potential dramatically change the field. proteins were amongst first macromolecules be studied XFEL include proof-of-principle demonstrations serial femtosecond (SFX), observation data can damage crystallographic structures, initial experiments towards recording information 2D arrays membrane proteins, time-resolved SFX, wide angle scattering emission spectroscopy studies. Conversely, methods now being applied using radiation. We believe context dependent choice or will accelerate progress novel insights understanding structure dynamics.
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