Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1
作者： Xiufang Guo , Severo Spradling , Maria Stancescu , Stephen Lambert , James J. Hickman
DOI: 10.1016/J.BIOMATERIALS.2013.02.061
关键词:
摘要: Although sensory neurons constitute a critical component for the proper function of nervous system, in vitro differentiation functional from human stem cells has not yet been reported. This study presents (SNs) neural progenitor cell line, hNP1, and their maturation defined, culture system without murine feeder layers. The SNs were characterized by immunocytochemistry was evaluated electrophysiology. Neural crest (NC) precursors, as one cellular derivatives culture, isolated, propagated, tested ability to generate neurons. hSC-derived SNs, well NC precursors provide valuable tools developing systems that model neuron-related circuits designing therapeutic models related diseases.
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