Limitations of one-dimensional population balance models of wet granulation processes☆

摘要: Most traditional models of wet granulation processes use one-dimensional population balances, which assume that granule size is the only independent property significantly affects growth behaviour. However, several other properties have been identified, can also strongly influence These include binder content, porosity, and primary particle distribution composition. balance implicitly conditions are spacially uniform throughout granulator. segregation has potential to occur in many commercial granulators. This will alter frequency velocity collisions between different sizes granule. Hence, current inadequate. need be expanded three or four dimensions size, composition (where applicable) as effects mixing within