Influence of aging on chemically induced hepatotoxicity: role of age-related changes in metabolism.

摘要: The effects on hepatotoxicity of age-associated changes in drug metabolism are not always straightforward. In the case allyl alcohol male rats, there is a good relationship between increased metabolic activation by liver dehydrogenase and enhanced old age. With regard to two other hepatotoxicants, some tentative conclusions about role can be drawn, but they must tempered with caution due gaps available information. Acetaminophen-induced reduced age, decreased formation toxic intermediate may reason. There prominent effect aging acetaminophen conjugation, shift from sulfation glucuronidation, this change does affect total clearance. situation carbon tetrachloride difficult interpret because final outcome unaltered Nevertheless, data suggest that an decrease counterbalanced loss resistance lipid peroxidation. These summarized Table 5. Again, it emphasized all these age-dependent toxicity could related systems necessarily involved hepatotoxicants. Future research needed identify pathways detoxification which occur result significant hepatotoxicity. entire sequence events at molecular level their sequelae cell, tissue intact animal should investigated, results confirmed more than one mammalian model aging. aim would basic mechanisms hazard for aged exposure compounds.