The elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients.

摘要: The aim of this study was to evaluate whether the platelet-to-lymphocyte ratio (PLR) could be used predict prognosis patients with nasopharyngeal carcinoma (NPC). Patients (n = 1261) who were diagnosed nonmetastatic NPC between January 2008 and December 2010 recruited. peripheral platelet lymphocyte counts retrieved, PLR calculated. Univariate multivariate Cox proportional hazards analyses assess their association PLR: overall survival (OS), cancer-specific (CSS), distant metastasis-free (DMFS). elevated PLR, using third quartile values (153.64) as optimal cutoff values, found associated significant decline in CSS (hazard [HR] 1.83, 95 % confidence interval [CI] 1.27–2.63, P < 0.001), OS (HR 1.81, CI 1.28–2.56, DMFS 1.60, 1.15–2.23, 0.005) that remained during multivariable (CCS HR 1.84, 1.26–2.67, 0.001; 1.28–2.61, 1.56, 1.11–2.19, 0.011). Subgroup indicated stratify effectively for early- or advanced-stage NPC, Epstein–Barr virus DNA levels ≥1500 copies/mL. In conclusions, poor CSS, OS, NPC; easily accessed variable based on a large amount cases analysis is valuable predicting NPC.