Mutagenicity and clastogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in L5178Y/TK+/−-3.7.2C mouse lymphoma cells☆
作者： Karen Harrigton-Brock , Carolyn L. Doerr , Martha M. Moore
DOI: 10.1016/0165-7992(95)00052-6
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摘要: Abstract 3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was tested without exogenous activation in L51785/TK +/− -3.7.2C mouse lymphoma cells for mutation at the thymidine kinase locus and clastogenicity. At a concentration of 0.75 μg/ml, induced mutant frequency 1027 per 10 6 survivors (survival = 11%). A concentration-related increase large small colony mutants observed, but majority MX formed colonies, consistent with positive clastogenic response that observed. primarily chromatid breaks rearrangements (30 4 chromosome aberrations 100 cells) μg/ml dose. These studies indicate induces broad spectrum genetic damage.
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