Risk of Esophageal Adenocarcinoma and Mortality in Patients With Barrett's Esophagus: A Systematic Review and Meta-analysis
作者： Marjolein Sikkema , Pieter JF De Jonge , Ewout W Steyerberg , Ernst J Kuipers , None
DOI: 10.1016/J.CGH.2009.10.010
关键词:
摘要: Background & Aims As the risk of esophageal adenocarcinoma (EAC) and mortality in patients with Barrett's esophagus (BE) are important determinants potential yield cost-effectiveness BE surveillance, clarification these factors is essential. We therefore performed a systematic review meta-analysis to determine incidence EAC due under surveillance. Methods Databases were searched for relevant cohort studies English language that reported BE. Studies had include histologically proven BE, documented follow-up, on A random effects model was used assessment heterogeneity by I 2 -statistic publication bias Begg's Egger's tests. Results Fifty-one included main analysis. The overall mean age 61 years; proportion males 64%. pooled estimate 6.3/1000 person-years follow-up (95% confidence interval, 4.7–8.4) considerable ( P = 79%). Nineteen data EAC. fatal 3.0/1000 2.2–3.9) no evidence .4; 7%). No found. Conclusions Patients at low malignant progression predominantly die causes other than This undermines surveillance supports search valid stratification tools identify minority likely benefit from
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