Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers

摘要: Rationale New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed develop new treatments biomarkers. Comparing blood transcriptional response other similar will advance knowledge disease pathways help distinguish with clinical presentations. Objectives To determine granulomatous diseases, tuberculosis, by comparing responses in these diseases. Methods We compared whole genome-wide profiles sarcoidosis, community acquired pneumonia primary lung cancer healthy controls, before after treatment, purified leucocyte populations. Measurements Main Results An Interferon-inducible neutrophil-driven signature was present both a higher abundance expression tuberculosis. Heterogeneity correlated significantly activity. Transcriptional revealed an over-abundance inflammatory transcripts. After successful treatment activity patients reduced. However glucocorticoid-responsive showed significant increase 144-blood transcripts were able from controls. Conclusions Tuberculosis profiles, dominated interferon-inducible transcripts, while distinct signatures, genes. There also differences between degree their activity, heterogeneity treatment.