Transforming growth factor-β1 hyperexpression in African American end-stage renal disease patients

摘要: Transforming growth factor-γ1hyperexpression in African American end-stage renal disease patients. End-stage (ESRD) is more frequent Americans (blacks) compared to Caucasian (whites). Identification of remediable causes the increased prevalence has potential reduce excess burden ESRD. Because fibrosis a correlate progressive failure and dominant feature ESRD, because transforming factor-beta1 (TGF-γ1) can induce insufficiency, we explored hypothesis that TGF-γ1 hyperexpression black ESRD patients white Our postulate was tested by determining circulating levels protein sera 56 42 treated chronic hemodialysis. A solid-phase sandwich enzyme-linked immunosorbent assay, specific for TGF-γ1, used quantify cohort. Additional cytokines implicated tissue repair/remodeling, interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α), were also measured. investigation demonstrated significantly higher concentration but not IL-6 or TNF-α blacks whites. observation hyperexpressed suggests mechanism (since result insufficiency experimental models) among population.