Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers
作者： Mariana L. Rodríguez‐López , José J. Martínez‐Magaña , Brenda Cabrera‐Mendoza , Alma D. Genis‐Mendoza , Fernando García‐Dolores
DOI: 10.1002/AJMG.B.32752
关键词:
摘要: Genetic factors have been implicated in suicidal behavior. It has suggested that one of the roles genetic suicide could be represented by effect variants on gene expression regulation. Alteration genes participating multiple biological systems brain demonstrated, so it is imperative to identify influence or its regulatory mechanisms. In this study, we integrated DNA methylation, expression, and genotype data from prefrontal cortex suicides regulation generally called quantitative trait locus (xQTLs). We 6,224 methylation loci 2,239 (eQTLs) completers. The xQTLs identified involved neurodevelopment cell organization. Two eQTLs (rs8065311 rs1019238) were previously associated with cannabis dependence, highlighting a candidate variant for increased risk subjects substance use disorders. Our findings suggest may regulate through modulation promoter enhancer activity, lesser extent, binding transcription factors.
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