A novel tumor-associated, developmentally regulated glycolipid antigen defined by monoclonal antibody ACFH-18.
作者： E D Nudelman , S B Levery , M R Stroud , M E Salyan , K Abe
DOI: 10.1016/S0021-9258(18)68335-8
关键词:
摘要: A mouse IgM monoclonal antibody, ACFH-18, was established after immunization of mice with the human gastric cancer cell line MKN74. The antibody reacts strongly gastrointestinal carcinoma and showed a clear dependence on degree differentiation cells. defines series glycolipid species extremely slow TLC mobility present in both acidic neutral fractions extract from adenocarcinoma original MKN74 Isolation structural study active glycolipids comparison reactivity having related structures revealed novel specificity. minimum requirement for maximal ACFH-18 identified as VII3Fuc-nLc10 (Structure below Fig. 8 text). Since did not react III3Fuc-nLc6 B below), which shares same terminal sequence VII3Fuc-nLc10, since it cross-reacted VII3Fuc-nLc8 (Z1 glycolipid) VII3Fuc,V3-Fuc,III3Fuc-nLc8 (Z3 glycolipid), is capable recognizing fucosyl residue plus an internal repeating N-acetyllactosamine proximal to ceramide, indicated by lines (Structures A, B, E-G). (Formula: see
sci-hub.st 参考文章(41)
S Hakomori, E Nudelman, S B Levery, R Kannagi, Novel fucolipids accumulating in human adenocarcinoma. I. Glycolipids with di- or trifucosylated type 2 chain Journal of Biological Chemistry. ,vol. 259, pp. 4672- 4680 ,(1984) , 10.1016/S0021-9258(17)43099-7
Janusz Dabrowski, Peter Hanfland, Heinz Egge, Structural analysis of glycosphinoglipids by high-resolution 1H nuclear magnetic resonance spectroscopy. Biochemistry. ,vol. 19, pp. 5652- 5658 ,(1980) , 10.1021/BI00565A030
Steven B. Levery, Sen-Itiroh Hakomori, [2] Microscale methylation analysis of glycolipids using capillary gas chromatography-chemical ionization mass fragmentography with selected ion monitoring Methods in Enzymology. ,vol. 138, pp. 13- 25 ,(1987) , 10.1016/0076-6879(87)38004-8
Reiji Kannagi, Sen-itiroh Hakomori, David L. Urdal, William W. Young, Robert Stroup, Nancy A. Cochran, Factors Affecting Expression of Glycolipid Tumor Antigens: Influence of Ceramide Composition and Coexisting Glycolipid on the Antigenicity of Gangliotriaosylceramide in Murine Lymphoma Cells Cancer Research. ,vol. 43, pp. 4997- 5005 ,(1983)
Hung-ju Yang, Sen-itiroh Hakomori, A Sphingolipid Having a Novel Type of Ceramide and Lacto-N-Fucopentaose III Journal of Biological Chemistry. ,vol. 246, pp. 1192- 1200 ,(1971) , 10.1016/S0021-9258(19)76958-0
Klaus Stellner, Hiroshi Saito, Sen-Itiroh Hakomori, Determination of aminosugar linkages in glycolipids by methylation Archives of Biochemistry and Biophysics. ,vol. 155, pp. 464- 472 ,(1973) , 10.1016/0003-9861(73)90138-0
U Dabrowski, P Hanfland, H Egge, S Kuhn, J Dabrowski, Immunochemistry of I/i-active oligo- and polyglycosylceramides from rabbit erythrocyte membranes. Determination of branching patterns of a ceramide pentadecasaccharide by 1H nuclear magnetic resonance Journal of Biological Chemistry. ,vol. 259, pp. 7648- 7651 ,(1984) , 10.1016/S0021-9258(17)42840-7
E H Holmes, G K Ostrander, S Hakomori, Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69). Journal of Biological Chemistry. ,vol. 260, pp. 7619- 7627 ,(1985) , 10.1016/S0021-9258(17)39654-0
H Rauvala, Gangliosides of human kidney. Journal of Biological Chemistry. ,vol. 251, pp. 7517- 7520 ,(1976) , 10.1016/S0021-9258(17)32880-6
S Hakomori, C M Patterson, E Nudelman, K Sekiguchi, A monoclonal antibody directed to N-acetylneuraminosyl-alpha 2 leads to 6-galactosyl residue in gangliosides and glycoproteins. Journal of Biological Chemistry. ,vol. 258, pp. 11819- 11822 ,(1983) , 10.1016/S0021-9258(17)44304-3