X chromosome transmission ratio distortion in Cftr +/- intercross-derived mice.
作者： Christina K Haston , Daryl G Humes , Melanie Lafleur
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摘要: Background Cystic fibrosis (CF) mice, created with a genetically engineered mutation in the Cystic transmembrane conductance regulator (Cftr) gene, may develop intestinal plugs which limit their survival past weaning. In studied population of mixed CF mice differences allelic ratios at particular loci, between surviving and lethal defect, were used to map cystic modifier gene one, Cfm1. Using this approach, we previously identified an X chromosome locus influence weaning C57BL/6J × BALB/cJ F2 mice. We also detected two regions transmission ratio distortion, independent Cftr genotype, limited dataset. To investigate these findings, study have genotyped 1208 three-week old 186 day E15.5 embryos, derived from congenic (C57BL/6J BALB/cJ) F1 +/- intercross, for putative distortion regions.
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