Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure
作者： M Yoshimura , H Yasue , E Morita , N Sakaino , M Jougasaki
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摘要: BACKGROUNDThis study was designed to examine the hemodynamic, renal, and hormonal effects of brain natriuretic peptide (BNP) infusion in patients with congestive heart failure (CHF) control subjects.METHODS AND RESULTSWe infused synthetic human BNP at a rate 0.1 micrograms/kg/min. decreased pulmonary capillary wedge pressure (control, from 5 +/- 1 2 mm Hg, p less than 0.01; CHF, 21 3 14 4 0.05) systemic vascular resistance 1,264 75 934 52 dyne.sec.cm-5; 2,485 379 1,771 195 0.01, respectively) increased stroke volume index 49.9 2.7 51.5 2.3 ml/m2, = NS; 25.6 3.8 32.0 3.9 0.01). significantly urine 0.7 7.5 1.9 ml/min; 0.8 0.2 5.3 1.0 respectively), excretion sodium 79.2 +...
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