Increasing rate of lymph node invasion in patients with prostate cancer treated with radical prostatectomy and lymph node dissection

摘要: Abstract Objectives To investigate lymph node invasion (LNI) rates in prostate cancer (PCa) patients. Recent studies demonstrated an inverse stage migration PCa patients toward more advanced and unfavorable diseases. We hypothesized that this trend is also evident LNI rates, treated with radical prostatectomy (RP) pelvic dissection (PLND). Patients methods Within the Surveillance, Epidemiology, End Results database (2004–2014), we identified who underwent RP PLND. Annual trends of PLND extent were plotted. Univariable multivariable logistic regression models tested hypothesis are increasing annually, even after adjustment for clinical or pathological characteristics. Of 96,874 PLND, 4.1% (n = 4,002) exhibited LNI. The rate (2.5%–6.6%.), mean (6.5–8.4) median (5–6) number removed nodes increased during study period. In models, contemporary year diagnosis was associated higher rate, when modeled as a continuous, categorized cubic spline variable, either (prostate specific antigen, tumor stage, biopsy Gleason group) characteristics (pathologic group), well (number nodes). Conclusion confirmed about over time This observation implies defined finding novel epidemiological North American European databases.