Familial risk of epilepsy: a population-based study

摘要: Almost all previous studies of familial risk epilepsy have had potentially serious methodological limitations. Our goal was to address these limitations and provide more rigorous estimates in a population-based study. We used the unique resources Rochester Epidemiology Project identify 660 Rochester, Minnesota residents born 1920 or later with incidence from 1935–94 (probands) their 2439 first-degree relatives who resided Olmsted County. assessed by comprehensive review relatives’ medical records, estimated age-specific cumulative standardized ratios for compared general population, according proband relative characteristics. Among probands, age 40 4.7%, increased 3.3-fold (95% confidence interval 2.75–5.99) population incidence. Risk greatest extent probands idiopathic generalized epilepsies (standardized ratio 6.0) associated intellectual motor disability presumed present birth, which we denoted ‘prenatal/developmental cause’ 4.3). without identified cause (including classified as ‘idiopathic’ ‘unknown cause’), significantly prenatal/developmental 4.1). Similarly, among cause, 3.8). In epilepsy, were 8.3 2.93–15.31) 2.5 0.92–4.00) focal epilepsy. 1.0 0.00–2.19) 2.6 1.19–4.26) Epilepsy greater offspring female than male this maternal effect restricted The results suggest that risks unknown may be influenced shared genetic mechanisms. They also some influences on are distinct. However, similar increase either (2.5-fold) (2.6-fold) reflect coexisting influences.